Bruk av antidepressive midler og antipsykotika er ikke uvanlig ved akutte korsryggssmerter, til tross for det ikke finnes dokumentert effekt av disse på smerter eller sykdomsforløp.Karst et al påpeker i sin studie at gentleman ofte må around doser på 10 mg THC per dag for å få suitable reduksjon i smerter 38, noe som for øvrig fortsatt ligg

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